Which medication used to reduce spasticity in multiple sclerosis commonly causes generalized weakness as a side effect?

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Multiple Choice

Which medication used to reduce spasticity in multiple sclerosis commonly causes generalized weakness as a side effect?

Explanation:
Baclofen reduces spasticity in MS by activating GABA-B receptors in the spinal cord, which dampens reflex excitability and lowers muscle tone. A well-known, dose-related side effect is generalized weakness or fatigue, stemming from the same CNS depressant action that decreases motor neuron output and overall muscle strength. While other drugs in the list have different primary uses or side effect profiles, the link between baclofen and generalized weakness is the most characteristic in the context of MS spasticity management.

Baclofen reduces spasticity in MS by activating GABA-B receptors in the spinal cord, which dampens reflex excitability and lowers muscle tone. A well-known, dose-related side effect is generalized weakness or fatigue, stemming from the same CNS depressant action that decreases motor neuron output and overall muscle strength. While other drugs in the list have different primary uses or side effect profiles, the link between baclofen and generalized weakness is the most characteristic in the context of MS spasticity management.

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